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Carnitine, on the other hand, primarily affects fatty acid transport and energy metabolism

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Metformin has been found to produce antidepressive effects by enhancing the responsiveness of the serotoninergic neurons in the dorsal raphe [47], but the main impact of GLP-1 is exerted by AMP-activated protein kinase (AMPK), a major cellular regulator of lipid and glucose metabolism [48]

263 People on incretin-based medications should prioritise adequate protein intake (1.21.60 g/kg of body weight per day, or an absolute target of 80120 g/day where appropriate), 254 combined with structured resistance exercise, to support preservation of lean mass during weight loss

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